Biology of splenic and nodal marginal zone lymphomas
نویسندگان
چکیده
منابع مشابه
Marginal zone lymphomas: management of nodal, splenic, and MALT NHL.
Marginal zone lymphomas are indolent B-cell lymphomas that originate from the marginal zone of B-cell follicles. For several subtypes, the initiation of disease appears to be a consequence of chronic infection and/ or inflammation. While the initial lymphoid hyperplasia is driven by physiologic antigenic stimulation, additional oncogenic events, such as chromosomal translocations leading to con...
متن کاملMarginal zone-related neoplasms of splenic and nodal origin.
BACKGROUND The marginal zone is an anatomically distinct B-cell compartment of lymphoid tissue with an abundant antigenic influx. Among marginal zone-derived lymphomas the WHO classification listed, in addition to extranodal marginal zone B-cell lymphoma of MALT type, two other marginal zone B-cell neoplasms: splenic marginal zone B-cell lymphoma (+/- villous lymphocytes) and nodal marginal zon...
متن کاملKaryometric Comparison of Splenic and Gastric Marginal Zone Lymphomas
BACKGROUND Marginal zone lymphomas are indolent B-cell lymphomas associated with autoimmunity and chronic inflammation. The two most frequent variants are mucosa associated lymphoid tissues marginal zone lymphomas and splenic marginal zone lymphomas. The aim of the study was to determine if it is possible to classify splenic and gastric lymphomas according to karyometric features. METHODS The...
متن کاملNodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes.
Nodal marginal zone B-cell lymphoma (MZL) is a rare and not extensively studied entity that accounts for approximately 2% of all non-Hodgkin lymphomas. Complementarity-determining regions 2 and 3 (CDR2, CDR3) of the immunoglobulin heavy-chain variable region (V(H)) genes were amplified by polymerase chain reaction (PCR), cloned, and sequenced in 8 patients with nodal MZL. All showed a potential...
متن کاملSplenic marginal zone lymphomas with peripheral CD5 expression.
We report 4 cases of splenic marginal zone lymphoma (SMZL) with peripheral CD5 positive, B-cell lymphocyto-sis. This unusual immunophenotypic discordance raises dilemmas in the diagnostic approach of these patients. In addition, this association may be related to a more aggressive clinical course, as 3 out of 4 of our patients died from progressive disease. Splenic marginal zone lymphoma (SMZL)...
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ژورنال
عنوان ژورنال: Annals of Lymphoma
سال: 2021
ISSN: 2616-2695
DOI: 10.21037/aol-20-38